The game utilizes procedural generation to make each playthrough a unique experience, while additional characters themed after important people from Abrahamic myth can radically change how the game plays. The player visits item rooms to acquire powerful upgrades and faces off against a boss on every floor, heading deeper and deeper downwards with each room cleared. Isaac wanders the maze that is the basement and beyond, collecting items and trinkets to slowly amass enough power to survive a confrontation with Mom and eventually greater foes beyond. Gameplay follows Isaac as he descends into the labyrinth underneath his house. Isaac discovers her intentions and manages to escape into the basement, where, still naked, he goes on the run as he fights off nightmares both physical and mental (using his own tears, no less), mutates into strange new forms, discovers memories of his own past, and ultimately confronts Mom in an effort to survive. After his fanatical Christian mother begins hearing the voice of God, she removes all of his worldly possessions and strips him naked, confines him to his bedroom, and unhesitatingly accepts a commission to kill him in sacrifice to prove her devotion. The story follows Isaac, a young boy who finds himself in possibly the worst situation imaginable. The Binding of Isaac is a Horror Comedy Roguelike Shoot 'Em Up made by Edmund McMillen and Florian Himsl, released in September 2011.

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